YIL-781 HYDROCHLORIDE

YIL-781 HYDROCHLORIDE

Stock Code: 3574528
Manufacturer Part No: SML1148-25MG
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£513.96 (exc VAT) per 25MG
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Application


YIL-781 has been used as a ghrelin receptor (GHSR) antagonist in combination with methanandamide (mAEA) to study its effect on gastric vagal afferent mechanosensitivity.


Biochem/physiol Actions


YIL-781 is a potent antagonist (Ki = 17 nM) of the growth hormone secretagogue receptor (GHS-R1). YIL-781 blocks ghrelin-induced reduction of insulin secretion in rat islets. In vivo, the compound YIL-781 improves glucose tolerance and reduces weight gain.


Packaging


5, 25 mg in glass bottle

Colour, white to yellow to light brown
Quality Level100
InChI keyQQGRMONBDBMLSP-FERBBOLQSA-N
InChI1S/C24H28FN3O2.ClH/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20;/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3;1H/t18-;
ManufacturerSIGMA-ALDRICH
SolubilityH2O: 2 mg/mL, clear (warmed)
Formpowder
Assay≥98% (HPLC)

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