Z944 HYDROCHLORIDE

Z944 HYDROCHLORIDE

Biochem/physiol Actions

Z944 is an orally available, state-dependent, potent and selective T-type calcium channel blocker (hCav3.1/Cav3.2/Cav3.3 IC50 by voltage clamp = 50/160/110 nM under ~30% inactivated state & 130/540/260 nM in the closed state) over non-T-type voltage-gated channels (rCaV2.2 IC50 = 11 µM/30% inactivated & 150 µM/closed; hERG/rCaV1.2/hNaV1.5 IC50 = 7.8/32/100 µM). Z944 effectively suppresses seizure activity in the GAERS (absence epilepsy rats from Strasbourg) model in vivo (10-30 mg/kg qod ip.) with no adverse cardiovascular effects or neurotoxicity.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576614 Z944 HYDROCHLORIDE white to beige SIGMA-ALDRICH 2-8°C H2O: 2 mg/mL, clear powder ≥98% (HPLC)
£388.61 (exc VAT) per EACH
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3576615 Z944 HYDROCHLORIDE white to beige SIGMA-ALDRICH 2-8°C H2O: 2 mg/mL, clear powder ≥98% (HPLC)
£119.93 (exc VAT) per EACH
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