Sacubitril Calcium Salt Hplc

Sacubitril Calcium Salt Hplc

Biochem/physiol Actions

Sacubitril (AHU377) is a prodrug inhibitor of the membrane metallo-endopeptidase neprilysin. Sacubitril forms half of the heart failure combination drug LCZ696, along with the angiotensin-receptor blocker Valsartan. Sacubitril (AHU377) is cojnverted by esterases into the active inhibitor LBQ657, which prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides. The AHU377 valsartan combination drug LCZ696 showed a reduction in the risk of cardiovascular death of 20% compared to the standard ACE inhibitor enalapril, and also a 21% drop in the risk of hospitalization.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574829 Sacubitril Calcium Salt Hplc white to beige 100 SIGMA-ALDRICH −20°C DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
£576.64 (exc VAT) per 25MG
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3574830 Sacubitril Calcium Salt Hplc white to beige 100 SIGMA-ALDRICH −20°C DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
£142.07 (exc VAT) per 5MG
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