PF-06456384 TRIHYDROCHLORIDE

PF-06456384 TRIHYDROCHLORIDE

Biochem/physiol Actions

PF-06456384 is a highly potent and selective inhibitor against voltage-gated sodium channel NaV1.7 (SCN9A; IC50 = 0.01, ﹤0.1, 75 nM against human, mouse, rat Nav1.7, respectively, by conventional patch clamp; human Nav1.7 IC50 = 0.58 nM by PatchExpress electrophysiology) with >300-fold selectivity over other human NaVs (IC50 = 3 nM/NaV1.2, 5.8 nM/NaV1.6, 75 nM/NaV1.7, 314 nM/NaV1.1, 1.45 µM/NaV1.4, 2.59 µM/NaV1.5, 6.44 µM/NaV1.3, 26 µM/NaV1.8).

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3573852 PF-06456384 TRIHYDROCHLORIDE white to beige SIGMA-ALDRICH room temp H2O: 2 mg/mL, clear powder ≥98% (HPLC)
£490.29 (exc VAT) per 25MG
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3573853 PF-06456384 TRIHYDROCHLORIDE white to beige SIGMA-ALDRICH room temp H2O: 2 mg/mL, clear powder ≥98% (HPLC)
£121.32 (exc VAT) per 5MG
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