(2R6R)-HYDROXYNORKETAMINE HYDROCHLORIDE

(2R6R)-HYDROXYNORKETAMINE HYDROCHLORIDE

Biochem/physiol Actions

(2R,6R)-Hydroxynorketamine is a ketamine metabolite that has rapid antidepressant activity without ketamine-related side effects. The NMDAR antagonist (R,S)-ketamine must be metabolized to (2S,6S;2R,6R)-hydroxynorketamine (HNK) to have antidepressant effects. The (2R,6R)-HNK enantiomer appears to be the enantiomer most responsible for antidepressant effects in a mouse study and unlike (2S,6S)-HNK, (2R,6R)-HNK caused no significant changes in locomotion or coordination. (2R,6R)-HNK does not seem to have the same addiction potential as ketamine, since mice did not self-administer pharmacologically relevant doses of (2R,6R)-HNK under the same conditions where ketamine was readily self-administered. The (2R,6R)-HNK antidepressant appears to involve activation of AMPA glutamate receptors rather than inhibition of NMDA glutamate receptors.

Packaging

5, 25 mg in glass bottle

No detailed specifications are available for this product.

There are no downloads for this product.

Code Description Colour Quality Level Manufacturer Solubility Form Assay Price Quantity
3575488 (2R6R)-HYDROXYNORKETAMINE HYDROCHLORIDE white to beige 100 SIGMA-ALDRICH H2O: 25 mg/mL, clear powder ≥98% (HPLC)
£612.86 (exc VAT) per 25MG
-
+
3575489 (2R6R)-HYDROXYNORKETAMINE HYDROCHLORIDE white to beige 100 SIGMA-ALDRICH H2O: 25 mg/mL, clear powder ≥98% (HPLC)
£189.43 (exc VAT) per 5MG
-
+