SUMO-1/SENTRIN-1 (GST-TAGGED)

SUMO-1/SENTRIN-1 (GST-TAGGED)

Application

SUMO-1 human has been used in pre-absorption for negative immunostaining to confirm the specificity of the small ubiquitin like modifier 1 (SUMO-1) antibody.

Biochem/physiol Actions

Small ubiquitin-like modifier 1 (SUMO-1) plays a key role in modulating survival, migration, and signal transduction in some cell lines. It can prevent in vitro migration and invasion of RA fibroblast-like synoviocytes (FLSs). Higher expression of SUMO-1 may result in joint destruction in rheumatoid arthritis (RA).

Conjugated to a variety of proteins by UbcH9, including RanGAP1, IκBα, and PML without the requirement of an equivalent E3 ubiquitin ligase.

General description

Small ubiquitin-like modifier 1 (SUMO-1), a protein, is one of the 5 SUMO paralogs expressed in mammalian cells with a low but significant homology with ubiquitin. This SUMO-1-GST fusion protein is produced from a DNA sequence corresponding to human SUMO-1 fused to a glutathione S-transferase (GST)-tag and is expressed in E. coli cells.

Physical form

Solution in 50 mM HEPES, pH 8.0, 150 mM NaCl and 1 mM DTT.

No detailed specifications are available for this product.

There are no downloads for this product.

Code Description Quality Level Manufacturer Storage Temp. Assay Price Quantity
3573883 SUMO-1/SENTRIN-1 (GST-TAGGED) 200 SIGMA-ALDRICH −70°C ≥95% (SDS-PAGE)
£535.12 (exc VAT) per 1MG
-
+
3573884 Sumo-1/sentrin-1 (gst-tagged) 200 SIGMA-ALDRICH −70°C ≥95% (SDS-PAGE)
£624.00 (exc VAT) per 500UG
-
+