BF-170 hydrochloride, >=98% (HPLC), solid

BF-170 hydrochloride, >=98% (HPLC), solid

Biochem/physiol Actions

BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC50 = 221 nM vs. EC50 = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimer′s disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD.

Caution

Product is air sensitive, store under inert gas.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price
3573279 BF-170 hydrochloride, >=98% (HPLC), solid orange 100 UYYPMQOFLJHJAW-UHFFFAOYSA-N 1S/C15H12N2.ClH/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15;/h1-10H,16H2;1H SIGMA-ALDRICH H2O: 10 mg/mL solid ≥98% (HPLC)
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3573280 BF-170 hydrochloride, >=98% (HPLC), solid orange 100 UYYPMQOFLJHJAW-UHFFFAOYSA-N 1S/C15H12N2.ClH/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15;/h1-10H,16H2;1H SIGMA-ALDRICH H2O: 10 mg/mL solid ≥98% (HPLC)
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