LBQ657

LBQ657

Biochem/physiol Actions

LBQ657 is the active metabolite of sacubitril. It is an inhibitor of the enkephalinase neprilysin (neutral endopeptidase, NEP) formed by the action of esterases on its prodrug sacubitril (AHU377), which is half of the heart failure combination drug Entresto, along with the angiotensin-receptor blocker Valsartan. LBQ657 prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575769 LBQ657 white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear powder ≥97% (HPLC)
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3575770 LBQ657 white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear powder ≥97% (HPLC)
Click Add to Quote for price and delivery
-
+