YODA1

YODA1

Application

Yoda1 has been used to investigate its effect on heterotrimeric Piezo1 channels.

Biochem/physiol Actions

Yoda1 is a specific activator of mouse and human cation channel Piezo1, a mechanosensitive channel that mediates Ca2+ influx on mechanical activation and has been linked to a role in blood vessel development. Yoda1 stabilizes the Piezo1 open channel. In red blood cells, this was followed by downstream activation of the KCa3.1 Gardos channel with resultant calcium influx and potassium and water efflux, causing shrinkage of the cells. Yoda1 is the first Piezo1 agonist, giving the first evidence of non-mechanical activation of a Piezo channel.

General description

Yoda1 is a novel synthetic small molecule developed to study the kinetics, regulation and function of the cation channel Piezo-type mechanosensitive ion channel component 1 (Piezo1).

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575084 YODA1 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 15 mg/mL, clear powder ≥98% (HPLC)
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3575085 YODA1 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 15 mg/mL, clear powder ≥98% (HPLC)
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