KT195

KT195

Biochem/physiol Actions

KT195 is a potent (IC50 = 10 nM) and selective inhibitor of A/β-hydrolase domain-containing 6 (ABHD6), a serine hydrolase that acts as an alternative hydrolase of the endocannabinoid 2-arachidonoylglycerol (2-AG). KT195 has negligible activity against other serine hydrolases such as DAGLβ and has been used as a control probe for studies of DAGLβ as well as being a probe on its own to study ABHD6. KT195 treatment of Neuro2A cells caused significant accumulation of 2-AG. KT195 also lowered interleukin-1β (IL-1β) secretion from lipopolysaccharide-treated macrophages suggesting ABHD6 involvement in this activity as well.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price
3574730 KT195 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
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3574731 KT195 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
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