BRUSATOL

BRUSATOL

Application

Brusatol has been used to study the protective role of Nrf2 (nuclear factor, erythroid 2 like 2 ) in intestinal ischemia/reperfusion induced injury.

Biochem/physiol Actions

Brusatol promotes Nrf2 (nuclear factor, erythroid 2 like 2 ) ubiquitination and degradation. Brusatol upregulates the expression of multiple ribosomal components and controls macromolecular complex function.

Brusatol (Brutasol) is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC50 ﹤1 µM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc. ﹤50 nM in A549 cells), including NRF2.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Form Assay Price Quantity
3575482 BRUSATOL white to beige 100 ZZZYHIMVKOHVIH-VILODJCFSA-N 1S/C26H32O11/c1-10(2)6-15(28)37-18-20-25-9-35-26(20,23(33)34-5)21(31)17(30)19(25)24(4)8-13(27)16(29)11(3)12(24)7-14(25)36-22(18)32/h6,12,14,17-21,29-31H,7-9H2, SIGMA-ALDRICH powder ≥95% (HPLC)
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3575483 BRUSATOL white to beige 100 ZZZYHIMVKOHVIH-VILODJCFSA-N 1S/C26H32O11/c1-10(2)6-15(28)37-18-20-25-9-35-26(20,23(33)34-5)21(31)17(30)19(25)24(4)8-13(27)16(29)11(3)12(24)7-14(25)36-22(18)32/h6,12,14,17-21,29-31H,7-9H2, SIGMA-ALDRICH powder ≥95% (HPLC)
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