MART-1 (26-35), Human, lyophilized powder
Amino Acid Sequence
Glu-Ala-Ala-Gly-Ile-Gly-Ile-Leu-Thr-Val
Biochem/physiol Actions
Melanoma-associated antigen recognized by T cells-1 (MART-1) is essential for the functioning of glycoprotein-100 (gp100). Overexpression of the gene has been observed in cutaneous melanoma (CM). In addition, deletion of Mart-1 gene leads to parotid metastatic melanoma.
General description
The peptide represents amino acids 26-35 of MART-1 protein that is the melanoma antigen recognized by T cells. This peptide mimics the natural epitope that is presented by T cells in humans with reactivity to melanoma cells.
Melanoma-associated antigen recognized by T cells-1 (MART-1), also known as Melan-A, is encoded by the gene mapped to human chromosome 9p24.1. The encoded protein is a hydrophobic transmembrane protein. MART-1 is mainly expressed in skin and retinae melanocytes.
Other Notes
Lyophilized from 0.1% TFA in H2O
Physical form
Lyophilized from 0.1% aqueous TFA
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