VATALANIB DIHYDROCHLORIDE

VATALANIB DIHYDROCHLORIDE

Biochem/physiol Actions

Vatalanib (PTK787, ZK 222584, CGP 79787D, CGP 79787 succinate) is an orally active anilinophthalazine derivative that exerts its anti-angiogenic efficacy by targeting receptor tyrosine kinase (RTK) VEGFR (VEGFR1/2 IC50 = 54/39 nM; IC50 ~30 nM against 100 ng/mL VEGF-C-induced VEGFR3 autophosphorylation in MEVCs) and, to a less extent, PDGFRβ, c-kit, c-fms (IC50 = 364, 600, 567 nM, respectively) in an ATP-competitive manner with much reduced or no potency toward >90 other kinases. Typical dosing ranges: 0.1-10 µM in cultures, 5 nM-200 µM (zebrafish) and 30-100 mg/kg (mice & rats via po. or ip) in vivo.

No detailed specifications are available for this product.

There are no downloads for this product.

Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576403 VATALANIB DIHYDROCHLORIDE white to beige SIGMA-ALDRICH 2-8°C H2O: 2 mg/mL, clear powder ≥98% (HPLC)
£92.63 (exc VAT) per 10MG
-
+
3576404 VATALANIB DIHYDROCHLORIDE white to beige SIGMA-ALDRICH 2-8°C H2O: 2 mg/mL, clear powder ≥98% (HPLC)
£312.00 (exc VAT) per 50MG
-
+