AH23848 hemicalcium salt, >=90% (HPLC), powder

AH23848 hemicalcium salt, >=90% (HPLC), powder

Application

AH23848 has been used as an prostaglandin E2 receptor 4 (EP4) receptor antagonist to study its effect on cAMP accumulation in monocrotaline (MCT28d) rat pulmonary arterial smooth muscle cells (PASMCs) and human T cell enriched peripheral blood mononuclear cells (PBMC). It has also been used to study its effect on the expressions of collagen-I, metalloproteinase (MMP-1), MMP-3, and EP4 gene expression in human tendon fibroblasts following interleukin (IL)-1? treatment.

Biochem/physiol Actions

EP4 prostanoid receptor antagonist with TP blocking activity.

AH23848 regulates nitric oxide (NO) production and reduces endogenous cAMP accumulation. This is carried out by declination of inducible nitric oxide synthase (iNOS) gene expression and acceleration of iNOS protein degradation in glomerular mesangial cells.

Features and Benefits

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Packaging

5, 25 mg in glass bottle

No detailed specifications are available for this product.

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Code Description Colour Quality Level InChI key InChI Manufacturer Form Assay Price Quantity
3573259 AH23848 hemicalcium salt, >=90% (HPLC), powder white to beige 100 JDEBIDDIERGZQY-XVFRBOAOSA-L 1S/2C29H35NO5.Ca/c2*31-26-20-27(35-21-22-12-14-24(15-13-22)23-8-4-3-5-9-23)25(10-6-1-2-7-11-28(32)33)29(26)30-16-18-34-19-17-30;/h2*1-5,8-9,12-15,25,27,29H,6-7 SIGMA-ALDRICH powder ≥90% (HPLC)
£1,179.75 (exc VAT) per 25MG
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3573260 AH23848 hemicalcium salt, >=90% (HPLC), powder white to beige 100 JDEBIDDIERGZQY-XVFRBOAOSA-L 1S/2C29H35NO5.Ca/c2*31-26-20-27(35-21-22-12-14-24(15-13-22)23-8-4-3-5-9-23)25(10-6-1-2-7-11-28(32)33)29(26)30-16-18-34-19-17-30;/h2*1-5,8-9,12-15,25,27,29H,6-7 SIGMA-ALDRICH powder ≥90% (HPLC)
£341.25 (exc VAT) per 5MG
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