M-110

M-110

Biochem/physiol Actions

M-110 is a highly isoform-selective, cell permeable and potent ATP-competitive inhibitor of the PIM kinase family that prefers PIM-3. M-110 is an inhibitor of Wnt/β-catenin signaling that act downstream of the symb-catenin destruction complex to inhibit both Wnt-induced and cancer associated constitutive Wnt signaling via destabilization of β-catenin. The compound chelates iron in vitro and in intact cells. M-110 inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 µM, with no activity on normal human peripheral blood mononuclear cells up to 40 µM.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574297 M-110 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 25 mg/mL, clear powder ≥98% (HPLC)
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3574298 M-110 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 25 mg/mL, clear powder ≥98% (HPLC)
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