NSC23766 TRIHYDROCHLORIDE

NSC23766 TRIHYDROCHLORIDE

Application

NSC23766 trihydrochloride has been used as a ras-related C3 botulinum toxin substrate 1 (RAC1) inhibitor.

Biochem/physiol Actions

NSC23766 is an inhibitor of Rac1, a Rho-family GTPase. The compound blocks activation by the guanine nucleotide exchange factors Trio and Tiam1, but does not affect interactions with RhoA or Cdc42. NSC23766 blocks ADP-mediated platelet aggregation. Inhibition of Rac1 by NSC23766 restores sensitivity to trastuzumab by restoring down-regulation of ErbB2.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574288 NSC23766 TRIHYDROCHLORIDE white to beige 100 SIGMA-ALDRICH −20°C H2O: 10 mg/mL, clear powder ≥97% (HPLC)
£739.61 (exc VAT) per 25MG
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3574289 NSC23766 TRIHYDROCHLORIDE white to beige 100 SIGMA-ALDRICH −20°C H2O: 10 mg/mL, clear powder ≥97% (HPLC)
£183.86 (exc VAT) per 5MG
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