YN1

YN1

Biochem/physiol Actions

YN1 is a potent inhibitor of PFKFB3 (6-Phosphfructo-2-kinase/fructose-2,6-bisphosphatase: IC50 = 670 nM). PFKFB3 is over expressed in many cancers, and catalyzes the production of fructose-2,6-bisphosphate, which can potentiate PFK1 activity, enhancing glycolysis in tumor cells. YN1 inhibits glycolysis and proliferation in HeLa cells.

Packaging

10, 50 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574279 YN1 white to beige 100 BMZFZTMWBCFKSS-UHFFFAOYSA-N 1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-15-10(13(11)18)5-6-12(17)14(15)19/h1-7,16-17,19H SIGMA-ALDRICH DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
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3574280 YN1 white to beige 100 BMZFZTMWBCFKSS-UHFFFAOYSA-N 1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-15-10(13(11)18)5-6-12(17)14(15)19/h1-7,16-17,19H SIGMA-ALDRICH DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
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