ZIBOTENTAN

ZIBOTENTAN

Biochem/physiol Actions

Zibotentan is a potent and selective endothelin ET(A) receptor antagonist with an IC50 of 21 nM for the ETA receptor subtype and no binding observed even at 10,000 nM for ETB.

Zibotentan has been found to inhibit cell proliferation, invasion and metastasis in cancer models. In clinical trials on patients with castration-resistant prostate cancer and bone metastasis, who were pain-free or had mild pain, zibotentan treatment resulted in better overall survival as compared to placebo.

General description

Zibotentan is an orally bioavailable, non-peptide ETA (endothelin) receptor-specific antagonist, with no activity against ETB receptor.

Packaging

5, 25 mg in glass bottle

No detailed specifications are available for this product.

There are no downloads for this product.

Code Description Colour Quality Level InChI key InChI Manufacturer Form Assay Price
3575070 ZIBOTENTAN white to beige 100 FJHHZXWJVIEFGJ-UHFFFAOYSA-N 1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25) SIGMA-ALDRICH powder ≥98% (HPLC)
You need to be logged in to see prices.
3575071 ZIBOTENTAN white to beige 100 FJHHZXWJVIEFGJ-UHFFFAOYSA-N 1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25) SIGMA-ALDRICH powder ≥98% (HPLC)
You need to be logged in to see prices.
You need to be logged in to see prices.