PF-06446846 HYDROCHLORIDE

PF-06446846 HYDROCHLORIDE

Biochem/physiol Actions

PF-06446846 is a selective orally active PCSK9 inhibitor that appears to act by causing the ribosome to stall when synthesizing PCSK9. PCSK9 binds to the LDL receptor, preventing it from removing LDL cholesterol from the blood. PF-06446846 was found to reduce plasma PCSK9 and total cholesterol levels in rats.

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Code Description Colour Manufacturer Solubility Form Assay Price Quantity
3573834 PF-06446846 HYDROCHLORIDE white to beige SIGMA-ALDRICH H2O: 2 mg/mL, clear powder ≥98% (HPLC)
£702.00 (exc VAT) per 25MG
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3573835 PF-06446846 HYDROCHLORIDE white to beige SIGMA-ALDRICH H2O: 2 mg/mL, clear powder ≥98% (HPLC)
£139.01 (exc VAT) per 5MG
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