FURAMIDINE DIHYDROCHLORIDE

FURAMIDINE DIHYDROCHLORIDE

Biochem/physiol Actions

Furamidine (DB75) binds to strings of AT base pair sequences in DNA′s minor groove. Furamidine was originally developed as an anti-parasitic compound for a variety of diseases including Chagas′ disease. Furamidine targets AT rich sequences in trypanosome kinetoplast minicircle DNA (kDNA), resulting in subsequent destruction of the kinetoplast and cell death. Furamidine has also been found to inihbit tyrosyl-DNA phosphodiesterase (Tdp1) and act as a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4µM.

General description

Furamidine dihydrochloride is an analog of the aromatic drug pentamidine and a substrate of the organic cation transporter 1 (OCT1). A number of prodrugs of furamidine dihydrochloride are being synthesised and are in clinical trial stages.

Packaging

5 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575086 FURAMIDINE DIHYDROCHLORIDE white to beige 100 SIGMA-ALDRICH −20°C H2O: 1 mg/mL, clear (warmed) powder ≥98% (HPLC)
£571.07 (exc VAT) per 25MG
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3575087 FURAMIDINE DIHYDROCHLORIDE white to beige 100 SIGMA-ALDRICH −20°C H2O: 1 mg/mL, clear (warmed) powder ≥98% (HPLC)
£124.94 (exc VAT) per 5MG
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