MoTP, >=98% (HPLC)

MoTP, >=98% (HPLC)

Application

MoTP may be used in cell signaling and differentiation studies.

Biochem/physiol Actions

MoTP (also known as 33N14) reversibly blocks the specification of neural crest cells into melanocytes in zebrafish studies. Differentiation of neural crest cell-derived melanoblasts proceeds to late developmental stages, but they fail to reach the terminal stage of melanin production and die. Melanocytotoxicity is dependent on tyrosinase activity which convert it into a toxic form. MoTP specifically ablates only cells that express tyrosinase at high levels, which in the embryo are limited to melanoblasts and newly formed melanocytes. MoTP should be a useful tool for elucidating melanocyte stem cell regeneration, recruitment, and maintenance.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3573999 MoTP, >=98% (HPLC) white to tan 100 YHKNLUTUXZDOQI-UHFFFAOYSA-N 1S/C14H21NO2S/c16-13-3-5-14(6-4-13)18-12-2-1-7-15-8-10-17-11-9-15/h3-6,16H,1-2,7-12H2 SIGMA-ALDRICH DMSO: ≥80 mg/mL powder ≥98% (HPLC)
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3574000 MoTP, >=98% (HPLC) white to tan 100 YHKNLUTUXZDOQI-UHFFFAOYSA-N 1S/C14H21NO2S/c16-13-3-5-14(6-4-13)18-12-2-1-7-15-8-10-17-11-9-15/h3-6,16H,1-2,7-12H2 SIGMA-ALDRICH DMSO: ≥80 mg/mL powder ≥98% (HPLC)
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