PF-05212377 SUCCINATE

PF-05212377 SUCCINATE

Biochem/physiol Actions

PF-05212377 (SAM-760; WYE-103760) is an orally available, high-affinity, selective 5-hydroxytryptamine (5-HT; serotonin) receptor 5-HT6 antagonist (Ki/IC50 = 0.53/1.06 nM against 3 nM [3H]-LSD for binding human 5-HT6). PF-05212377 modulates glutamate and acetylcholine release in the cerebral cortex and hippocampus in rodents with in vivo pro-cognitive efficacy.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3573864 PF-05212377 SUCCINATE white to beige SIGMA-ALDRICH room temp DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
£348.21 (exc VAT) per EACH
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3573865 PF-05212377 SUCCINATE white to beige SIGMA-ALDRICH room temp DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
£85.80 (exc VAT) per EACH
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