ANLE138B

ANLE138B

Biochem/physiol Actions

Anle138b, an oligomer modulator, inhibits neuronal degeneration. It rescues neurons from the aggregationeffects of ?-synuclein.

Anle138b is a fluorescent inhibitor of α-synuclein and prion-protein (PrPSc) aggregation that reduces the progression of prion and Parkinson′s disease in animal models. Anle138b extends the survival of mice infected with prions. Anle138b strongly inhibits BSE-derived and human prions. The fluorescence strongly increases upon binding with α-synuclein fibrils. Apparently, Anie138b binds to hydrophobic pockets in the fibrils.

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5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price
3575014 ANLE138B white to beige 100 RCQIIBJSUWYYFU-UHFFFAOYSA-N 1S/C16H11BrN2O2/c17-12-3-1-2-10(6-12)13-8-14(19-18-13)11-4-5-15-16(7-11)21-9-20-15/h1-8H,9H2,(H,18,19) SIGMA-ALDRICH DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
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3575015 ANLE138B white to beige 100 RCQIIBJSUWYYFU-UHFFFAOYSA-N 1S/C16H11BrN2O2/c17-12-3-1-2-10(6-12)13-8-14(19-18-13)11-4-5-15-16(7-11)21-9-20-15/h1-8H,9H2,(H,18,19) SIGMA-ALDRICH DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
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