LEUKADHERIN-1

LEUKADHERIN-1

Biochem/physiol Actions

Leukadherin-1 is an agonist of complement receptor-3 (CR3) and exhibits anti-inflammatory activity. It is an allosteric agonist that activates integrin by binding to a different site from the ligand binding. Leukadherin-1 plays an important role in the margination and adhesion of neutrophils to the endothelial lining of the blood vessels.

Leukadherin-1 is an agonist of integrin CD11b/CD18 that can increase the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils. Also, Leukadherin-1 decreases leukocyte recruitment and reduced arterial narrowing after injury in rats.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price
3574204 LEUKADHERIN-1 , yellow to orange to brown 100 SIGMA-ALDRICH 2-8°C DMSO: 3 mg/mL, clear (warmed) powder ≥98% (HPLC)
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3574205 LEUKADHERIN-1 , yellow to orange to brown 100 SIGMA-ALDRICH 2-8°C DMSO: 3 mg/mL, clear (warmed) powder ≥98% (HPLC)
You need to be logged in to see prices.
You need to be logged in to see prices.