ML348

ML348

Biochem/physiol Actions

ML348 is a substrate-competitive, reversible and APT1-selective acyl-protein thioesterase (APT) inhibitor (IC50/Ki = 840 nM/300 nM against APT1; IC50 & Ki >10 µM against APT2). ML348 effectively inhibits cellular APT1 activity in cultures (by >95% in HEK293T & mouse T cells; 5 µM for 4 h) and in mice in vivo (by >90% in lung/heart/kidney and by ~50% in brain tissue 4 h post 50 mg/kg i.p. dosing) without affecting more than 15 cellular serine hydrolases and APT2.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575524 ML348 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
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3575525 ML348 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
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