ANI9

ANI9

Application

Ani9 has been used to find out the inappropriate modulation of the membrane protein functions that are involved in the 198 ADGRG2- or Gq-mediated regulation of fluid reabsorption in the efferent ductules.

Biochem/physiol Actions

2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide (Ani9), the most potent inhibitor, is the structural analog of Ani7. It may be considered as a novel candidate for drug therapy of cancer, hypertension, pain, diarrhea and asthma.

Ani9 is a potent and highly selective anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) inhibitor that completely inhibited ANO1 chloride current with submicromolar potency. Ani9 does not affect the intracellular calcium signaling and CFTR chloride channel activity.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575415 ANI9 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 25 mg/mL, clear powder ≥98% (HPLC)
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3575416 ANI9 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 25 mg/mL, clear powder ≥98% (HPLC)
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