4-OCTYL ITACONATE

4-OCTYL ITACONATE

Application

4-Octyl itaconate has been used:to study its anti-inflammatory effects in macrophagesto treat bone-marrow-derived macrophages (BMDMs) for BMDMstimulation with nuclear factor-erythroid factor 2-related factor 2 (NRF2)-activating carboxylic acid compoundsto study its effects on collagen1 expression in systemic Sclerosis (SSc) dermal fibroblasts

Biochem/physiol Actions

4-Octyl itaconate (4-OI) possesses anti-inflammatory effects. It can obstruct glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and glycolysis in macrophages. It can be a good substitute to itaconate due to its thiol reactivity. The electrophilic ? and ?-unsaturated moieties of 4-OI might help to alkylate the thiol in cysteine residues of proteins through Michael reaction.

The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function. 4-Octyl itaconate is a cell-permeable itaconate derivative that decreases cytokine production and is protective against lipopolysaccharide-induced lethality in vivo. Esterases in mouse myoblast cells and macrophages hydrolyze it to itaconate, which alkylates cysteine residues on KEAP1, allowing the transcription factor Nrf2 to increase the expression of anti-oxidant and anti-inflammatory downstream genes.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576167 4-OCTYL ITACONATE white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
£466.61 (exc VAT) per 25MG
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3576168 4-OCTYL ITACONATE white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
£115.61 (exc VAT) per 5MG
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