CP-456773 SODIUM SALT

Descriptions

Application

CP-456773 sodium salt has been used : In in vivo experiments to study the neuroprotective action of ketogenic diet. To study the effect of inhibition of NLRP3 (nod-like receptor protein 3) inflammasome activity on tumor progression in mouse models.To study the cholesterol crystal-mediated IL-1b (interleukin-1b) response in placental explants.

Biochem/physiol Actions

CP-456773 sodium salt (CRID3) was found to act as a cytokine release inhibitory drug and inhibitor of the NLRP3 inflammasome. CP-456773 sodium salt inhibits interleukin 1β (IL-1β) secretion and caspase 1 processing.

CP-456773 is known to inhibit the release of other proinflammatory cytokines such as IL-1? and IL-18. It is also referred to as MCC950.

Legal Information

Pfizer is a registered trademark of Pfizer, Inc.

Sold for research purposes under agreement from Pfizer Inc.

Other Notes

This compound was developed by Pfizer for Cytokines & Growth Factors research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

Packaging

5, 25 mg in glass bottle

Specifications

No detailed specifications are available for this product.

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Code	Description	Colour	Quality Level	InChI key	InChI	Manufacturer	Storage Temp.	Solubility	Form	Assay	Price		Quantity
3573688	CP-456773 SODIUM SALT	white to beige	100	LFQQNXFKPNZRFT-UHFFFAOYSA-M	1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1	SIGMA-ALDRICH	room temp	H<SUB>2</SUB>O: 20 mg/mL, clear	powder	≥98% (HPLC)	£591.96 (exc VAT) per 25MG		- +
3573689	CP-456773 Sodium Salt	white to beige	100	LFQQNXFKPNZRFT-UHFFFAOYSA-M	1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1	SIGMA-ALDRICH	room temp	H<SUB>2</SUB>O: 20 mg/mL, clear	powder	≥98% (HPLC)	£146.25 (exc VAT) per 5MG		- +