KY-05009

KY-05009

Biochem/physiol Actions

KY-05009 is a Traf2- and Nck-interacting kinase (TNIK) inhibitor that inhibits the epithelial-to-mesenchymal transition (EMT) in cancer cells.

KY-05009 is also known as (5-(4-methylbenzamido)-2-(phenylamino) thiazole-4-carboxamide). It prevents the proliferation induced by interleukin-6 and promotes cell death by blocking Wnt signaling in multiple myeloma (MM) cells. KY-05009 is a novel aminothiazole, which possesses anti-cancer activity in human colorectal cancer cells. KY-05009 prevents migration and invasion stimulated by TGF-?1 (transforming growth factor beta 1).

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3575000 KY-05009 light yellow to dark yellow 100 WCEDGRTWDSHZHF-UHFFFAOYSA-N 1S/C18H16N4O2S/c1-11-7-9-12(10-8-11)16(24)22-17-14(15(19)23)21-18(25-17)20-13-5-3-2-4-6-13/h2-10H,1H3,(H2,19,23)(H,20,21)(H,22,24) SIGMA-ALDRICH DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
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3575001 KY-05009 light yellow to dark yellow 100 WCEDGRTWDSHZHF-UHFFFAOYSA-N 1S/C18H16N4O2S/c1-11-7-9-12(10-8-11)16(24)22-17-14(15(19)23)21-18(25-17)20-13-5-3-2-4-6-13/h2-10H,1H3,(H2,19,23)(H,20,21)(H,22,24) SIGMA-ALDRICH DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
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