CINACIGUAT HYDROCHLORIDE

CINACIGUAT HYDROCHLORIDE

Biochem/physiol Actions

Cinaciguat, also known as BAY 58-2667, is a novel activator of guanylate cyclase. It is used in the treatment of acute decompensated heart failure (ADHF). It has been reported that cinaciguat possesses cardiovascular effects.

Cinaciguat activates sGC (soluble guanylate cyclase) independently of NO. Cinaciguat binds to sGC′s NO-sensory H-NOX domain when it is heme-depleted. Also, the compound Cinaciguat protects sGC from oxidation-induced ubiquitin-triggered degradation.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price
3575042 CINACIGUAT HYDROCHLORIDE white to beige 100 LLHMBJOVHATVSP-UHFFFAOYSA-N 1S/C36H39NO5.ClH/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28;/h1-5,8-11,1 SIGMA-ALDRICH DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
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3575043 CINACIGUAT HYDROCHLORIDE white to beige 100 LLHMBJOVHATVSP-UHFFFAOYSA-N 1S/C36H39NO5.ClH/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28;/h1-5,8-11,1 SIGMA-ALDRICH DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
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