BPV(PHEN)

BPV(PHEN)

Biochem/physiol Actions

bpV(phen) (potassium bisperoxo(bipyridine)oxovanadate) shows protective effect against disease progression in leishmaniasis by mediating NO-dependent microbicidal action.

bpV(phen) is an insulin receptor kinase (IRK) activator and an inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(phen) are 38 nM for PTEN compared to 343 nM for PTPβ and 920 nM for PTP-1β. bpV(phen) has anti-inflammatory effects in oxidative stress including inhibitory effects on oxidative stress-induced cardiomyocyte injury that may be partially modulated by the action of ROS on PTEN. It may also be involved in differentiation.

Other Notes

Light Sensitive

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574208 BPV(PHEN) faintly yellow to dark yellow 100 SIGMA-ALDRICH &minus;20&deg;C H<SUB>2</SUB>O: 20 mg/mL, clear powder &ge;95% V basis
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3574209 BPV(PHEN) faintly yellow to dark yellow 100 SIGMA-ALDRICH &minus;20&deg;C H<SUB>2</SUB>O: 20 mg/mL, clear powder &ge;95% V basis
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