NQ301

NQ301

Biochem/physiol Actions

NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574769 NQ301 , faint red to dark red 100 LSQZKIQSQHZVQS-UHFFFAOYSA-N 1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3 SIGMA-ALDRICH DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
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3574770 NQ301 , faint red to dark red 100 LSQZKIQSQHZVQS-UHFFFAOYSA-N 1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3 SIGMA-ALDRICH DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
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