FLI-06

FLI-06

Biochem/physiol Actions

FLI-06 is an inhibitor of Notch signaling. FLI-06 acts upstream of α-secretase and β-secretase cleavage, disrupting intracellular trafficking and processing of the Notch signaling pathway and inhibiting general secretion at a step before exit from the endoplasmic reticulum (ER). This inhibition is accompanied by a tubule-to-sheet morphological transition of the ER. FLI-06 does not act on the cytoskeleton, but causes a complete disruption of the Golgi in a manner different from that of Brefeldin A or Golgicide A. FLI-06 is the first compound acting that early in the secretory pathway.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price
3574309 FLI-06 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
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3574310 FLI-06 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
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