GSK690

GSK690

Biochem/physiol Actions

GSK690 (GSK354) is a cell-permeable pyrrolidinylmethoxypyridine-based compound that inhibits lysine-specific demethylase 1 (LSD1; KDM1A) in a potent and reversible manner (IC50= 90 nM) without affecting MAO-A activity (IC50>200 μM). GSK690 is shown to induce the expressions of CD86 (EC50= 1.4 μM in THP1 cells) and LY96 (EC50= 423 nM in MV4-11 cells), and prevent adipogenesis in murine preadipocyte cultures.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576289 GSK690 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
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3576290 GSK690 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
Click Add to Quote for price and delivery
-
+