S3QEL 2

S3QEL 2

Biochem/physiol Actions

S3QEL 2 is a selective inhibitor of superoxide production from the outer Q-binding site of mitochondrial respiratory complex site III (IIIQo) without altering oxidative phosphorylation. Site IIIQo is the primary source of mitochondrial reactive oxygen species (ROS) and has been implicated in a broad range of ROS-mediated signaling and pathology. S3QEL 2 lowered HIF-1α induction, protected against ROS-induced, JNK-mediated cell stress in pancreatic beta-cells, and decreased the oxidative stress-induced apoptosis that limits the yield of functional β-cells from intact islets.

S3QEL 2, a cell permeable substituted allopurinol, is also known as 1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine.

Packaging

10, 50 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Price Quantity
3575078 S3QEL 2 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 5 mg/mL, clear powder
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3575079 S3QEL 2 white to beige 100 SIGMA-ALDRICH −20°C DMSO: 5 mg/mL, clear powder
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