NMDI14 97% (HPLC)

NMDI14 97% (HPLC)

Application

NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:to study its effects on differentiating cardiomyocytesto study its effects on zebrafish pdzk1 gene-knockout embryosto analyze its effects on the apoptosis of colorectal cancer cells

Biochem/physiol Actions

NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575050 NMDI14 97% (HPLC) white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 0.2 mg/mL, clear (warmed) powder ≥97% (HPLC)
£626.79 (exc VAT) per 25MG
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3575051 NMDI14 97% (HPLC) white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 0.2 mg/mL, clear (warmed) powder ≥97% (HPLC)
£164.36 (exc VAT) per 5MG
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