CP-809;101 FUMARATE

CP-809;101 FUMARATE

Biochem/physiol Actions

CP-809,101 is a potent and high-affinity 5-hydroxytryptamine receptor 2C (5-HT2C) full agonist with only weaker partial agonist activity toward 5-HT2A & 5-HT2B (cellular Ca2+ mobilization EC50 in nM/efficiency = 0.11/93% and 0.06/97% with human and rat 5-HT2C, respectively; 153/67%/human 5HT2A, 65.3/57%/human 5HT2B, 119/79%/rat 5HT2A) and much reduced or little affinity toward other receptors, ion channels and uptake sites tested. CP-809,101 exhibits antipsychotic efficacy in reducing conditioned avoidance response/CAR (ED50 = 4.8 mg/kg s.c.) and locomotor activity (ED50 in mg/kg via s.c. = 2/rats, 1/mice; no effect up to 10 mg/kg in 5-HT2C-knockout mice), while oral administration is reported to suppress spontaneous and nocturnal food intake as well as fasting-induced refeeding in rats (~8% and ~24% reduction of cumulative food intake and body weight in 4 days, respectively; 30 mg/kg/day p.o.).

Legal Information

Pfizer is a registered trademark of Pfizer, Inc.

Sold for research purposes under agreement from Pfizer Inc.

No detailed specifications are available for this product.

There are no downloads for this product.

Code Description Colour Manufacturer Storage Temp. Form Assay Price Quantity
3573839 CP-809;101 FUMARATE white to beige SIGMA-ALDRICH −20°C powder ≥98% (HPLC)
£391.39 (exc VAT) per 25MG
-
+
3573840 CP-809;101 FUMARATE white to beige SIGMA-ALDRICH −20°C powder ≥98% (HPLC)
£96.80 (exc VAT) per 5MG
-
+