AURORA-A INHIBITOR I

AURORA-A INHIBITOR I

Application

Aurora-A Inhibitor I has been used to study its effect on cell viability of human megakaryoblastic cell line (SET-2) and human erythroleukemia cell line (HEL) by methylthiazoletetrazolium (MTT) assay.

Biochem/physiol Actions

Aurora-A Inhibitor I, also known as TC?S7010, stimulates G2/M cell cycle arrest and apoptosis in ARID1A ?/? cells.

Aurora-A Inhibitor I is a potent inhibitor of Aurora kinase A with an IC50 of 3.4 nM and 1000-fold selectivity for Aurora A over Aurora B (better than VX-680) and even higher for CDKs. Antiproliferative IC50 values were in the vicinity of 1 µM against the human colorectal cancer cell line HCT116.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574197 AURORA-A INHIBITOR I white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
£644.89 (exc VAT) per 25MG
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3574198 AURORA-A INHIBITOR I white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
£190.82 (exc VAT) per 5MG
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