Chromanol 293B, >=98% (HPLC), powder

Chromanol 293B, >=98% (HPLC), powder

Application

Chromanol 293B has been used in the inhibition of calcium and cyclic adenosine monophosphate (cAMP)-activated potassium channels in human epithelial cell lines. Chromanol 293B has been used in patch-clamp electrophysiology studies in cardiomyocytes.

Biochem/physiol Actions

Blocker of the slow delayed rectifier K+ current via KCNQ1 channels

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Chromanol 293B enantiomer is a potent inhibitor of potassium channel protein (KvLQT1). In human atrial myocytes, chromanol 293B inhibits repolarization potassium currents. Chromanol 293B improves glucose-stimulated insulin secretion (GSIS) in pancreas by modulating potassium voltage-gated channel (KCNQ1).

Packaging

10, 50 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3573309 Chromanol 293B, >=98% (HPLC), powder white 100 HVSJHHXUORMCGK-UONOGXRCSA-N 1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m0/s1 SIGMA-ALDRICH DMSO: 18 mg/mL powder ≥98% (HPLC)
£288.32 (exc VAT) per 10MG
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3573310 Chromanol 293B, >=98% (HPLC), powder white 100 HVSJHHXUORMCGK-UONOGXRCSA-N 1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m0/s1 SIGMA-ALDRICH DMSO: 18 mg/mL powder ≥98% (HPLC)
£858.00 (exc VAT) per 50MG
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