PR-619, >=95% (HPLC)

PR-619, >=95% (HPLC)

Application

PR-619 has been used:as a component of lysis buffer and also as a deubiquitinase inhibitor to treat proteins derived from SILAC-labeled Jurkat cellsas a pan-deubiquitinase inhibitor to study its effect on adenoassociated virus (AAV) transductionin radioimmunoprecipitation assay buffer (RIPA) buffer used for ubiquitination assays

Biochem/physiol Actions

PR-619 is a cell permeable broad spectrum deubiquitylating enzymes (DBUs) inhibitor. PR-619 induces the accumulation of polyubiquitylated proteins in cells without directly affecting proteasome activity.

Packaging

1, 5 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574086 PR-619, >=95% (HPLC) white to beige 100 ZXOBLNBVNROVLC-UHFFFAOYSA-N 1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12) SIGMA-ALDRICH DMSO: 5 mg/mL (clear solution) powder ≥95% (HPLC)
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3574087 PR-619, >=95% (HPLC) white to beige 100 ZXOBLNBVNROVLC-UHFFFAOYSA-N 1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12) SIGMA-ALDRICH DMSO: 5 mg/mL (clear solution) powder ≥95% (HPLC)
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