JNJ-55511118

JNJ-55511118

Biochem/physiol Actions

JNJ-55511118 is an orally available, brain penetrant, potent and selective negative modulator of AMPA receptors that requires the presence of the accessory protein CACNG8 (TARP-γ8). JNJ-55511118 exhibit potent inhibition of neurotransmission within hippocampus, and a strong anti-convulsant effect.

JNJ-55511118 is also known as 5-[2-chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydrobenzimidazol-2-one. It acts as an anticonvulsant or neuroprotectant. It is considered as a reversible ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor inhibitor, mainly in the hippocampus region.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575340 JNJ-55511118 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 25 mg/mL, clear powder ≥98% (HPLC)
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3575341 JNJ-55511118 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 25 mg/mL, clear powder ≥98% (HPLC)
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