ISRIB

ISRIB

Application

ISRIB (integrated stress response inhibitor) has been used as an inhibitor of integrated stress response.

Biochem/physiol Actions

ISRIB (integrated stress response inhibitor) as a drug, imparts resistance to the cells against the downstream effects of eukaryotic initiation factor 2 (eIF2)? phosphorylation such as activating transcription factor 4 (ATF4) and eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) induction.

ISRIB is a blood- brain barrier penetrant, potent and selective inhibitor of integrated stress response (ISR) that impairs adaptation to ER stress. ISRIB is a potent inhibitor of PERK signaling, which potently reverses the effects of eIF2a phosphorylation and restores the cells translation capacity. ISRIB enhances cognitive memory in rodents.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price
3574161 ISRIB white to beige 100 HJGMCDHQPXTGAV-IYARVYRRSA-N 1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)/t17 SIGMA-ALDRICH DMSO: 1 mg/mL, clear (warmed) powder ≥98% (HPLC)
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3574162 ISRIB white to beige 100 HJGMCDHQPXTGAV-IYARVYRRSA-N 1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)/t17 SIGMA-ALDRICH DMSO: 1 mg/mL, clear (warmed) powder ≥98% (HPLC)
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