FC-99 HYDROCHLORIDE

FC-99 HYDROCHLORIDE

Biochem/physiol Actions

FC-99 is known to affect the levels of serum immunoglobulin. It might be therapeutically beneficial in systemic lupus erythematosus.

FC-99 is a benzenediamine derivative that inhibits LPS-induced IRAK4 phosphorylation/activation and downstream signaling events (5-45 μM; murine RAW 264.7 & peritoneal macrophages), including IRAK1 (a TLR3 pathway negative regulator) degradation, p38/ERK/JNK activation, and cytokines production. FC-99 inhibits RSV replication (50 μM; A549) and poly(I:C)-indued IRF3/IFN-A/JAK/STAT1 signalling in cultures (0.5-50 μM; murine peritoneal macrophages), and ameliorates sepsis induction following caecal ligation puncture (CLP) in mice in vivo (100/70/32.5% motality in 7 days with 0/30/100 mg/kg i.p. 2 h prior to CLP).

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576218 FC-99 HYDROCHLORIDE white to beige SIGMA-ALDRICH 2-8°C H2O: 2 mg/mL, clear (warmed) powder ≥98% (HPLC)
£449.89 (exc VAT) per 25MG
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3576219 FC-99 HYDROCHLORIDE white to beige SIGMA-ALDRICH 2-8°C H2O: 2 mg/mL, clear (warmed) powder ≥98% (HPLC)
£111.71 (exc VAT) per 5MG
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