YIL-781 HYDROCHLORIDE

Descriptions

Application

YIL-781 has been used as a ghrelin receptor (GHSR) antagonist in combination with methanandamide (mAEA) to study its effect on gastric vagal afferent mechanosensitivity.

Biochem/physiol Actions

YIL-781 is a potent antagonist (Ki = 17 nM) of the growth hormone secretagogue receptor (GHS-R1). YIL-781 blocks ghrelin-induced reduction of insulin secretion in rat islets. In vivo, the compound YIL-781 improves glucose tolerance and reduces weight gain.

Packaging

5, 25 mg in glass bottle

Specifications

Colour	, white to yellow to light brown
Quality Level	100
InChI key	QQGRMONBDBMLSP-FERBBOLQSA-N
InChI	1S/C24H28FN3O2.ClH/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20;/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3;1H/t18-;
Manufacturer	SIGMA-ALDRICH
Solubility	H2O: 2 mg/mL, clear (warmed)
Form	powder
Assay	≥98% (HPLC)