LDK1305

LDK1305

Biochem/physiol Actions

LDK1305 is a selective positive allosteric modulator of CB1 that promote the binding of the agonist CP55940 and inhibits binding of orthosteric inverse agonist SR141716A. LDK1305 is a beta-arrestin-biased ligand that induces cellular internalization of the receptor and recruitment of β-arrestin 2 in HEK293 cells. It stimulates also β-arrestin 1-dependent phosphorylation of the downstream kinases, ERK1/2, MEK, and Src.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576534 LDK1305 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
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3576535 LDK1305 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
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