Tocainide hydrochloride, >=98% (HPLC), solid

Tocainide hydrochloride, >=98% (HPLC), solid

Application

Tocainide hydrochloride may be used in cell signaling studies.

Biochem/physiol Actions

Tocainide hydrochloride is a primary amine analog of lidocaine (lignocaine), used for the treatment of tinnitus. It blocks the sodium channels in the pain-producing foci in the nerve membranes and renders an analgesic effect in trigeminal neuralgia.

Tocainide hydrochloride is a sodium channel blocker; Class IB antiarrhythmic.

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Tocainide is voltage-dependent and use-dependent sodium channel blocker (class IB type antiarrhythmic); Ki = 115 µM in blockade of inactivated-state sodium channels; IC50 = 985µM in blockade of Na+ currents at a holding potential (HP) of -140 mV; IC50 = 254 µM in blockade of Na+ currents at HP -70 mV; IC50 = 523 µM in blockade of Na+ currents at tonic block (-100 mV); IC50 = 248 µM for use-dependent block at 10 Hz.

Packaging

10, 50 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Form Assay Price Quantity
3576963 Tocainide hydrochloride, >=98% (HPLC), solid white 100 AMZACPWEJDQXGW-UHFFFAOYSA-N 1S/C11H16N2O.ClH/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12;/h4-6,9H,12H2,1-3H3,(H,13,14);1H SIGMA-ALDRICH solid ≥98% (HPLC)
£242.36 (exc VAT) per 10MG
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3576964 Tocainide hydrochloride, >=98% (HPLC), solid white 100 AMZACPWEJDQXGW-UHFFFAOYSA-N 1S/C11H16N2O.ClH/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12;/h4-6,9H,12H2,1-3H3,(H,13,14);1H SIGMA-ALDRICH solid ≥98% (HPLC)
£903.96 (exc VAT) per 50MG
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