IN-1130

IN-1130

Biochem/physiol Actions

IN-1130 is a potent inhibitor of the activin receptor-like kinase ALK-5 (Type 1 TGF1β recptor). The compound inhibits phosphorylation of Smad-2 with an IC50 of 36 nM. IN-1130 inhibits renal fibrosis, and also reduces tumor volume in prostate tumor xenografts in murine models.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price
3574865 IN-1130 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
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3574866 IN-1130 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
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