AR-R17779 HYDROCHLORIDE

AR-R17779 HYDROCHLORIDE

Biochem/physiol Actions

AR-R17779 is a nicotinic acetylcholine receptor alpha7 full agonist that targets α7 nAChR with high affinity (Ki = 92 nM/rat α7 against 5 nM α-BTX vs.16 µM/rat α4β2 against 3 nM (-)-nicotine) and selectivity (EC50 = 6.2/10/12.7 µM using human/rat/monkey α7 nAChR-Xenopus oocyte by whole cell voltage clamp, no antagonistic activity against acetylcholine using human α4β2-, α3β4-, α3β2-, α3β2α5-expressing oocytes or antagonistic activity against 5-HT using rat 5HT3a-exxpressing oocytes). AR-R17779 exhibits cognition-improving efficacy in rats (1-20 mg/kg s.c) and mice (1-20 mg/kg i.p.) in vivo and is widely employed for studying other α7 nAChR-dependent physiological functions.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575747 AR-R17779 HYDROCHLORIDE white to beige SIGMA-ALDRICH −20°C H2O: 2 mg/mL, clear powder ≥97% (HPLC)
£474.96 (exc VAT) per 25MG
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3575748 AR-R17779 HYDROCHLORIDE white to beige SIGMA-ALDRICH −20°C H2O: 2 mg/mL, clear powder ≥97% (HPLC)
£117.98 (exc VAT) per 5MG
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