Torin2 has been used:to examine its effect on LC3B-II levels in BORCS5- KO cellsto determine its potent activity (IC50less than 1 ?M) against A2780-cis ovarian cancer cellsin western blot analysis
Biochem/physiol Actions
Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor. Torin2 has an IC50 of 0.25 nM and 800-fold greater selectivity for mTOR than PI3K.