TAKINIB

TAKINIB

Application

Takinib has been used as an inhibitor of transforming 28 growth factor - ?-activated kinase -1 (TAK-1) in human leukemia monocyticTHP-1 cells. It may be used as a TAK1 inhibitor in Jurkat cells.

Biochem/physiol Actions

Takinib is a selective inhibitor of TAK1/MAP3K7 kinase, which is a member of the MAP3K family and a key regulator of cell death. It binds in the TAk1 ATPbinding pocket with an IC50 value of 9.5 nM. Takinib selectively induced apoptosis following TNF-α stimulation in rheumatoid arthritis and breast cancer.

General description

Takinib belongs to the aminobenzimidazole class of inhibitors.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price
3575974 TAKINIB white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
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3575975 TAKINIB white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear powder ≥98% (HPLC)
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